14° Congresso da Sociedade Latino Americana de Biomateriais, Orgãos Artificiais e Engenharia de Tecidos – SLABO
(5ª Edição do Workshop de Biomateriais, Engenharia de Tecidos e Orgãos Artificiais – OBI)
20 a 24 de Agosto de 2017 - Maresias - SP - Brasil

José Mauro Granjeiro, Graduated in Dentistry from the University of Sao Paulo Bauru Dental School (1989), Master in Science (Cellular and Structural Biology) from State University of Campinas (1994) and Doctor in Science (Chemistry) from the State University of Campinas (1998). He carried out postdoctoral fellow in Cell and Molecular Biology at the Chemical Institute of University of Sao Paulo (1999-2000). Currently work as Associate Professor at the Dental School of Fluminense Federal University and Senior Scientist in Metrology and Quality at the National Institute of Metrology, Quality and Technology (Inmetro). He has experience in Bone Biology and Biomaterials, studying toxicity of biomaterials, cell-based therapy, tissue repair induced by growth factors and biomolecules, alternative methods to animal use, equivalent tissues development, search for new biomarkers of nanometric particules toxicity and nanostructured materials. Coordinates the Nanotox Network and the Brazilian team in the European consortium NanoReg (FP7). Belongs to the National Council of Biotechnology (CNB) and Consultative Council of Nanotechnology (CCNano/MCTI). Was the coordinator of the National Council for the Control of Animal Experimentation (CONCEA) in 2014 and 2015.


Strategies for hazard analysis of nanomaterials: Brazilian National Institute of Metrology experience.

José Mauro Granjeiro

Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Brasil

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for
urgent action by regulators. The integration of governmental initiatives to promote the competitiveness is the main goal of Brazilian Nanotechnology Initiative (BNI). National Laboratories for Nanotechnology (SisNANO) possess the key infrastructure and personnel to support the research, development and innovation. Networks of laboratories focusing in toxicology are responsible to develop and disseminate the best approaches to investigate the hazard of nanoparticles and manufactured nanomaterials. Our group participated in two European consortiums (Nanovalid and Nanoreg) focusing the development of standardized protocols for the physic-chemical-biological analysis of nanoparticles. OECD guidelines have been shown to be able for hazard analysis of nanomaterials, besides some adjustments in protocols would be necessary. However, we still lack a scientifically sound understanding of the mechanisms, factors and properties that ultimately drive their interaction, transport and fate of nanoparticles in real systems. This knowledge gap is one of the main source of uncertainties when assessing the hazard of MNM and making them safe. Based on this scenario, a regulatory research strategy in nanotechnology has being proposed help regulatory agencies and industries.

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